Patriots vs Bills: Who Is Favored To Win?
The Patriots and Bills have matched up 133 times, with the Patriots leading the overall record, 80-52-1. They have officially split the season series, and there is a chance they meet again in the playoffs.
Here's how Massachusetts betting apps think those games will go:
Week 5: Patriots at Bills
Sunday, October 5, 8:20 p.m. EST. The Bills lost 23-20 to the Patriots, failing to cover the spread. The under hit.
| Moneyline | Over/Under | Spread |
| BUF -375 | NE +295 | 49.5 | BUF -7.5 |
Week 15: Bills at Patriots
Sunday, December 14, 1:00 p.m. EST. The Bills won 35-31 to cover the spread. The over hit.
| Moneyline | Over/Under | Spread |
| BUF -115 | NE -105 | 50.5 | BUF-1.5 |
Latest Patriots Bills Odds, Updates & News
Here are the key updates impacting the next iteration of the Patriots vs Bills rivalry.
- 📆 April 21: Buffalo signs DB Tre'Davious White.
- 📆 March 28: The Patriots sign WR Stefon Diggs.
- 📆 March 14: New England signs S Marcus Epps, WR Mack Hollins, and DT Khyiris Tonga.
- 📆 March 13: The Patriots sign CB Carlton Davis III, DT Milton Williams, OT Morgan Moses, and LB Robert Spillane.
- 📆 March 12: Buffalo signs DE Joey Bosa and WR Josh Palmer.
- 📆 March 9: The Bills release DE Von Miller.
- 📆 February 25: Buffalo re-signs WR Khalil Shakir to a four-year contract extension.
- 📆 January 12: The Patriots hire Mike Vrabel as Head Coach.
Patriots vs Bills Odds: What the Spread Tells Us
The Patriots vs Bills spread indicates that Buffalo is favored in both meetings, more so in the first game. The spread for the Patriots-Bills is expected to change as the season progresses, but for now, the Bills are favored by 8.5 points in Week 5 at home, while the Pats are favored in Week 15. These two games will be paramount in the Patriots playoff chances given the tough divisional matchup.
Patriots vs Bills Odds: What the Over/Under Tells Us
The over/under or total for the Patriots-Bills games is the same for both meetings, so far. Sportsbooks like BetMGM Massachusetts have the over/under for both matchups set at 46.5. In 2024, the first Patriots-Bills game total was 45, and the second matchup was 39, so keep that in mind as these games approach.
Patriots vs Bills Odds: What the Moneyline Tells Us
The Patriots vs Bills moneyline favored Buffalo heavily in Week 5 at -410 at sportsbooks like Fanatics Sportsbook Massachusetts. Based on implied probability, this gives Buffalo an 80.4% chance of beating the Patriots on SNF. The moneyline for the Patriots-Bills Week 15 matchup favors the Bills by 1.5 points.
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Patriots-Bills Rivalry
The Patriots-Bills rivalry spans 60 years, dating back to 1960 when both teams were members of the American Football League. The two teams have combined for 17 AFL/AFC championships, the most of any two teams in the NFC East.
The rivalry has been competitive over those 60 years, with the Patriots leading the matchup all-time at 80-52-1. However, the majority of those wins came during the Tom Brady era, with the quarterback having a record of 32-3 against Buffalo in his time with New England.
Since Brady's departure in 2020, the Bills are 8-3 against the Patriots, including a 47-17 beatdown in the 2021-22 NFL playoffs.
Author
Blake Weishaar is a content strategist and fact-checker for BetMassachusetts.com. He has nearly a decade of experience in the gambling industry as a writer and editor at Fantini Research and Eilers & Krejcik Gaming. He is committed to making sure readers have the most up-to-date and correct information about Massachusetts betting regulations and information.
