Patriots vs Bills Odds, Lines, Picks & More

The New England Patriots will play their AFC East rival Buffalo Bills twice in the span of 3 weeks to end the 2024 NFL season. With these AFC East rivals wrapping up the regular season, these games could prove crucial when it comes to playoff seeding. 

Here you'll find the best odds and lines for the Patriots vs Bills found at Massachusetts sports betting sites. 

Khalil Shakir vs Myles Bryant

Patriots vs Bills: Who Is Favored To Win?

The next iteration of the Patriots-Bills rivalry will be renewed in December, when the Patriots head to Buffalo to play the Bills for the first time in a three-week span. 

Here's how Massachusetts betting apps think those games will go:

Week 16: Patriots at Bills

Sunday, December 22, 1 p.m. EST

MoneylineOver/UnderSpread
BUF -395 | NE +31044.5BUF -8.5

Week 18: Bills at Patriots

TBD

MoneylineOver/UnderSpread
BUF -180 | NE +15044.5BUF -3.5

Latest Patriots Bills Odds, Updates & News

Here are the key updates impacting the next iteration of the Patriots vs Bills rivalry.

  • 📆 May 15: The 2024-2025 NFL schedule is released, revealing that the Patriots and Bills will play each other in Week 16 and Week 18
  • 📆 April 25: The Patriots select UNC QB Drake Maye with the third overall pick of the NFL Draft.  
  • 📆 April 3: The Bills trade standout WR Stefon Diggs to Houston in exchange for a 6th round pick in 2024 and 5th round pick in 2025 for a 2nd round pick in 2025 via Minnesota. 
  • 📆 March 15: The Bills add former Washington WR Curtis Samuel and former Atlanta WR Mack Hollins
  • 📆 March 13: WR Gabe Davis laves the Bills in free agency to sign with Jacksonville. 
  • 📆 March 6: The Bills release long-time defensive starters CB Tre'Davious White and S Jordan Poyer.
  • 📆 January 12: The Patriots promote inside linebackers coach Jerod Mayo to head coach. 
  • 📆 January 11: Long-time Patriots head coach Bill Belichick, the bane of the Bills over the last two decades, leaves New England. 

Patriots vs Bills Odds: What the Spread Tells Us

The Patriots vs Bills spread indicates that Buffalo is favored in both meetings, more so in the first game. The spread for the Patriots-Bills is expected to change as the season progresses, but for now, the Bills are favored but 8.5 in Week 16 and favored once again in Week 18, this time by 3.5 pts. These two games will be paramount in the Patriots playoff chances given the tough divisional matchup. 

Patriots vs Bills Odds: What the Over/Under Tells Us

The over/under or total for the Patriots-Bills games is the same for both meetings, so far. Sportsbooks like BetMGM Massachusetts have the over/under for both matchups set at 44.5. In 2023, both Patriots-Bills games went over that total, so keep that in mind as these games approach. 

Patriots vs Bills Odds: What the Moneyline Tells Us

The Patriots vs Bills moneyline favors Buffalo heavily in Week 16 at -395 at sportsbooks like Fanatics Sportsbook Massachusetts. The moneyline for the Patriots-Bills Week 18 matchup still favors Buffalo, but much less so at -180.

Promos for the Bills vs Patriots Games

There are plenty of sports betting promos available for the Bills vs Patriots game. In fact, there are over $4K in bonuses available from the top Massachusetts sports betting promos right now!

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  • Massachusetts bettors must be 21+ and present to place wagers in the state. Gambling problem in Massachusetts? Call 1-800-327-5050 to speak with a trained specialist free and confidentially 24/7. Full Terms and Conditions Apply.
  • Massachusetts bettors must be 21+ and present to place wagers in the state. Play it smart from the start! GameSenseMA.com or call 1-800-GAM-1234. Gambling problem in Massachusetts? Call 1-800-327-5050 to speak with a trained specialist free and confidentially 24/7. Full T&Cs apply.

Patriots-Bills Rivalry

The Patriots-Bills rivalry spans 60 years, dating back to 1960 when both teams were members of the American Football League. The two teams have combined for 17 AFL/AFC championships, the most of any two teams in the NFC East. 

The rivalry has been competitive over those 60 years, with the Patriots leading the matchup all-time at 78-50-1. However, the majority of those wins came during the Tom Brady era, with the quarterback having a record of 32-3 against Buffalo in his time with New England. 

Since Brady's departure in 2020, the Bills are 7-2 against the Patriots, including a 47-17 beatdown in the 2021-2022 NFL playoffs. 

Author

Blake Weishaar is a commercial editor and fact-checker for BetMassachusetts.com. He has nearly a decade of experience in the gambling industry as a writer and editor at Fantini Research and Eilers & Krejcik Gaming. He is committed to making sure readers have the most up-to-date and correct information about Massachusetts betting regulations and information.

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